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Introduction: Restless legs syndrome (RLS) is a neurological-motor disorder in which most patients tend to shake their legs during sleep and describe it as an unpleasant feeling. The aims of this study were to determine the prevalence of RLS, its relationship with demographic characteristics, depression, and insomnia and comparison of the mentioned variables in the group with and without RLS.
Methods: This was a case-control analytic study. The sample consisted of 429 adults aged 17-70 years who had referred all the psychiatric and neurological clinics of Yazd (center of Iran) in 2019. Participants were selected by cluster sampling method. Research tools included a demographic questionnaire, the Beck Depression Inventory (BDI-II), Insomnia Severity Index (ISI), and an International Restless Legs Syndrome Questionnaire (IRLSQ). The data were analyzed by SPSS-21, chi-square, Pearson correlation coefficient, independent t-test, and linear regression. Significant level was considered 0.05.
Results: The mean and standard deviation of the age of participants was 34.43± 10.82. Furthermore, the mean and standard deviation of the age group with RLS was 36.07± 10.95 while in group without RLS was 33.92± 10.75. Prevalence of RLS in adults was 23.5% (n= 101), in women was 32% (n= 66) and in men was 28.7% (n= 35). The t-test showed patients with RLS had a higher degree of depression and insomnia than those without RLS (p<0.05). Multiple linear regression also showed that insomnia (β= 0.36), age (β= 0.13), and depression (β= 0.15) had a significant effect on RLS score. 
Conclusion: The prevalence of RLS among adults in Yazd is high. Severe insomnia, depressed mood, and aging are considered as important factors in predicting this disease. According to what was mentioned early detection, prevention, and treatment of this disorder in adults is necessary.

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Introduction: In recent years, different values of the general prevalence of restless legs syndrome have been reported in various studies and its related factors in Iranian society are not known. The aim of this study was to evaluate the prevalence and factors associated with restless legs syndrome in Iran by meta-analysis.
Methods:  This study was performed based on PRISMA checklist. There was a time limit from 1^st July 2014 to 11^th November 2019 for documents obtained from English and Persian databases such as Magiran, Sid, Medilib, Iranmedex, Irandoc, Civilica, ISC, Pubmed, Scopus, Springer, and Google Scholar Engine. Data were searched and extracted independently by two researchers and finally, a group decision was made with the presence of a third observer. All reviewed articles with selection criteria were evaluated qualitatively by the STROBE checklist. Comprehensive Meta analysis (CMA-2) software was used to analyze the data by meta-analysis random effects model.
Results: The prevalence of restless legs syndrome was estimated to be 32.9% (95% CI: 22.9- 44.7) in 24 studies with 26474 Iranian subjects that 65.9% of whom were women. The prevalence of this disorder was 47.6% in Iranian women (95% CI: 28.7-67.2%) and 36.7% in Iranian men (95% CI: 21.4-55.3%). The most and the least prevalence of restless legs syndrome based on geographical region were respectively in east (44.3%) and north of the country (15.5%) and this difference was significant based on meta-regression (p <0.05). The prevalence of this syndrome was 50% in hemodialysis patients, 35% in other diseases, 25.7% in pregnant women, 20.2% in elderly and 13.8% in adults.
Conclusion: The prevalence of restless legs syndrome in Iran is higher than other parts of the world based on different studies. Therefore, early detection, prevention and treatment of this disorder in adults, especially women, is essential.