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1- Department Biostatics & Epidemiology, Health Faculty, ShahidSadoughi University Of Medical sciences,Yazd, Iran
2- Yazd Cardiovascular Research Center, ShahidSadoughi University Of Medical Sciences, Yazd, Iran , drnamayandeh@gmail.com
3- Diabetes Research Center, ShahidSadoughi University Of Medical Sciences, Yazd, Iran
4- Yazd Cardiovascular Research Center, ShahidSadoughi University Of Medical Sciences, Yazd, Iran
Abstract:   (107 Views)
Introduction: Given the high impact of Diabetes Mellitus type II (DM II) on human's health, identification of risk factors to prevent from its development is essential. The role of uric acid in DM II development and progress has not ever been well investigated. So, the causal relationship of uric acid with diabetes needs further longitudinal cohort studies. This study targeted at investigating the attributed risk of hyperuricemia for the onset of DM II.
Materials and methods: In the present study, 1641 non-diabetic people selected through multi-stage random cluster sampling were followed up for 10 years (2006 - 2016). During the study, data on the variables of the study were collected and entered in SPSS16 and it was used to analyze them. To calculate the attributions of hyperuricemia in the risk of developing diabetes, Levin's formulas and attributable risk related to the prevalence of exposure were used.
Results: Findings showed that 54.8% of people with hyperuricemia were suffered from DM II., whereas 28.2% of people with normal uric acid level developed diabetes. The Attributable Risk (AR) of hyperuricemia and 75thpercentile of serum uric acid for DM II calculated by the weighted attributable risk formula and were 3.6 % and 24.2 %, respectively. With the treatment of high uric acid, the probability for incidence of diabetes in hyperuricemia patients reduced to 24.2% over a 10-year period.
Conclusion: A significant relationship was observed between high blood uric acid and the risk of diabetes. So, necessary measures should be taken to treat the hyperuricemia patients in order to prevent incidence of diabetes caused by high blood acid uric.
     
Review: Research | Subject: Epidemiology
Received: 2018/04/22

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