Volume 7, Issue 4 (Oct-Dec 2018)
JCHR 2018, 7(4): 200-206 |
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Karimi A, Namayandeh S M, Fallahzadeh H, Rahmanian M, Sadr-Bafghi S M, Soltani M, et al . Population Attributable Risk (PAR) of Hyperuricemia for Diabetes Mellitus in 20-74-Year-Old Population of Yazd during a 10-Year Longitudinal Cohort: Yazd Healthy Heart Cohort (YHHC) in Iran. JCHR 2018; 7 (4) :200-206
URL: http://jhr.ssu.ac.ir/article-1-430-en.html
URL: http://jhr.ssu.ac.ir/article-1-430-en.html
Ahmad Karimi1 
, Seyedeh Mahdieh Namayandeh * 2, Hosein Fallahzadeh3 , Masoud Rahmanian4 , Seyed Mahmoud Sadr-Bafghi5 , Mohammadhosein Soltani6 , Leila Hadiani6 , Samaneh Jalilian6 , Mohammad-Taghi Sareban-Hassanabadi6 , Mojtaba Mohammadhoseini3 , Fatemeh Majidpour3 , Maryam Askari5
, Seyedeh Mahdieh Namayandeh * 2, Hosein Fallahzadeh3 , Masoud Rahmanian4 , Seyed Mahmoud Sadr-Bafghi5 , Mohammadhosein Soltani6 , Leila Hadiani6 , Samaneh Jalilian6 , Mohammad-Taghi Sareban-Hassanabadi6 , Mojtaba Mohammadhoseini3 , Fatemeh Majidpour3 , Maryam Askari5
1- Research Center of Prevention and Epidemiology of Non-Communicable Disease, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. . Department of Communicable Disease Surveillance, Abadeh Health Center, Shiraz University of Medical Sciences, Shiraz, Iran
2- Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Research Center of Prevention and Epidemiology of Non-Communicable Disease, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , drnamayandeh@gmail.com
3- Research Center of Prevention and Epidemiology of Non-Communicable Disease, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5- Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6- Yazd Cardiovascular Research Center, ShahidSadoughi University Of Medical Sciences, Yazd, Iran
2- Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Research Center of Prevention and Epidemiology of Non-Communicable Disease, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , drnamayandeh@gmail.com
3- Research Center of Prevention and Epidemiology of Non-Communicable Disease, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5- Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6- Yazd Cardiovascular Research Center, ShahidSadoughi University Of Medical Sciences, Yazd, Iran
Abstract: (6598 Views)
Introduction: Taking into consideration the high impact of Diabetes Mellitus type II (DM II) on human's health, identification of risk factors to prevent its development seems essential. Further studies are needed to ensure the positive role of uric acid in the onset of diabetes. This study targeted at investigating the attributed risk of hyperuricemia for the onset of DM II.
Methods: In the present study, 1641 non-diabetic people, selected through multi-stage random cluster sampling, were followed up for 10 years (2006 - 2016). During the study, data on the variables of the study were collected and entered in SPSS 16 which was used to analyze the data. To calculate the attributions of hyperuricemia in the risk of developing diabetes, Levin's formulas and attributable risk related to the prevalence of exposure during these ten years were used.
Results: Findings showed that 54.8% of people with hyperuricemia suffered from DM II., whereas 28.2% of people with normal uric acid level developed diabetes. The Attributable Risk (AR) of hyperuricemia and 75th percentile of serum uric acid for DM II were calculated by the weighted attributable risk formula which was 3.6 % and 24.2 %, respectively. With the treatment of high uric acid, the probability of the incidence of diabetes in hyperuricemia patients was reduced to 24.2% over a 10-year period.
Conclusion: In this study, there was a significant correlation between high uric acid level and the risk of diabetes. Therefore, necessary measurements should be taken to treat the hyperuricemia patients in order to prevent the incidence of diabetes caused by high blood acid uric.
Methods: In the present study, 1641 non-diabetic people, selected through multi-stage random cluster sampling, were followed up for 10 years (2006 - 2016). During the study, data on the variables of the study were collected and entered in SPSS 16 which was used to analyze the data. To calculate the attributions of hyperuricemia in the risk of developing diabetes, Levin's formulas and attributable risk related to the prevalence of exposure during these ten years were used.
Results: Findings showed that 54.8% of people with hyperuricemia suffered from DM II., whereas 28.2% of people with normal uric acid level developed diabetes. The Attributable Risk (AR) of hyperuricemia and 75th percentile of serum uric acid for DM II were calculated by the weighted attributable risk formula which was 3.6 % and 24.2 %, respectively. With the treatment of high uric acid, the probability of the incidence of diabetes in hyperuricemia patients was reduced to 24.2% over a 10-year period.
Conclusion: In this study, there was a significant correlation between high uric acid level and the risk of diabetes. Therefore, necessary measurements should be taken to treat the hyperuricemia patients in order to prevent the incidence of diabetes caused by high blood acid uric.
Review: Research |
Subject:
Epidemiology
Received: 2018/04/22 | Accepted: 2018/12/31 | Published: 2018/12/31
Received: 2018/04/22 | Accepted: 2018/12/31 | Published: 2018/12/31
References
1. Papatheodorou K, Banach M, Edmonds M, et al. Complications of diabetes. Journal of Diabetes Research. 2015; 2015(Article ID 189525): 1-5. [http://dx.doi.org/10.1155/2015/189525]
2. Chaudhary K, Malhotra K, Sowers J, et al. Uric Acid-key ingredient in the recipe for cardiorenal metabolic syndrome. Cardiorenal Medicine. 2013; 3(3): 208-220. [DOI:10.1159/000355405] [PMID] [PMCID]
3. DeBoer MD, Dong L, Gurka MJ. Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006. Metabolism-Clinical and Experimental. 2012; 61(4): 554-561. [DOI:10.1016/j.metabol.2011.09.003] [PMID] [PMCID]
4. Krzystek-Korpacka M, Patryn E, Kustrzeba-Wojcicka I, et al. Gender-specific association of serum uric acid with metabolic syndrome and its components in juvenile obesity. Clinical Chemistry and Laboratory Medicine. 2011; 49(1): 129-136. [DOI:10.1515/CCLM.2011.011] [PMID]
5. Tseng CH. Independent association of uric acid levels with peripheral arterial disease in Taiwanese patients with Type 2 diabetes. Diabetic Medicine. 2004; 21(7): 724-729. [DOI:10.1111/j.1464-5491.2004.01239.x] [PMID]
6. Wun Y, Chan C, Lui C. Hyperuricaemia in Type 2 diabetes mellitus. Diabetes, Nutrition & Metabolism. 1999; 12(4): 286-291. [PMID]
7. Nakagawa T, Mazzali M, Kang D-H, et al. Hyperuricemia causes glomerular hypertrophy in the rat. American Journal of Nephrology. 2003; 23(1): 2-7. [DOI:10.1159/000066303] [PMID]
8. Muscelli E, Natali A, Bianchi S, et al. Effect of insulin on renal sodium and uric acid handling in essential hypertension. American Journal of Hypertension. 1996; 9(8): 746-752. [DOI:10.1016/0895-7061(96)00098-2]
9. Nasri H. Commentary on: Is uric acid an indicator of metabolic syndrome in the first-degree relatives of patients with type 2 diabetes?. Journal of Research in Medical Sciences. 2013; 18(3): 267-268. [PMID] [PMCID]
10. Nasri H, Ardalan M-R, Rafieian-Kopaei M. On the occasion of world hypertension day 2014: A nephrology point of view. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences. 2014; 19(9): 911-912. [PMID] [PMCID]
11. Orchard TJ, Dorman JS, Maser RE, et al. Prevalence of complications in IDDM by sex and duration: pittsburgh epidemiology of diabetes complications study II. Diabetes. 1990; 39(9): 1116-1124.
https://doi.org/10.2337/diabetes.39.9.1116 [DOI:10.2337/diab.39.9.1116] [PMID]
12. Kodama S, Saito K, Yachi Y, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care. 2009; 32(9): 1737-1742. [DOI:10.2337/dc09-0288] [PMID] [PMCID]
13. Taylor R. Type 2 diabetes: etiology and reversibility. Diabetes Care. 2013; 36(4): 1047-1055. [DOI:10.2337/dc12-1805] [PMID] [PMCID]
14. Tsur A, Harman-Bohem I, Buchs A, et al. The guidelines for the diagnosis prevention and treatment of type 2 diabetes mellitus--2005. Europe PMC. 2006; 145(8): 583-586.
15. Lv Q, Meng X-F, He F-F, et al. High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PloS One. 2013; 8(2): e56864. [DOI:10.1371/journal.pone.0056864] [PMID] [PMCID]
16. Benfer KA, Weir KA, Bell KL, et al. Longitudinal cohort protocol study of oropharyngeal dysphagia: relationships to gross motor attainment, growth and nutritional status in preschool children with cerebral palsy. BMJ Open. 2012; 2(4): e001460. [DOI:10.1136/bmjopen-2012-001460] [PMID] [PMCID]
17. Mirzaei M, Soltani M, Namayandeh M, et al. Sodium and potassium intake of urban dwellers: nothing changed in Yazd, Iran. Journal of Health, Population, and Nutrition. 2014; 32(1): 111-117. [PMID] [PMCID]
18. Association AD. Diagnosing diabetes and learning about prediabetes 2015. Available at: URL: http://www.diabetes.org/diabetes-basics/diagnosis/?loc=db-slabnav. Accessed Nov 21, 2018.
19. Messerli FH, Frohlich ED, Dreslinski GR, et al. Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Annals of Internal Medicine. 1980; 93(6): 817-821. [DOI:10.7326/0003-4819-93-6-817] [PMID]
20. Kahn HA, Sempos CT. Statistical Methods in Epidemiology. New York: Oxford University; 1989.
21. Dehghan A, Van Hoek M, Sijbrands EJ, et al. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care. 2008; 31(2): 361-362. [DOI:10.2337/dc07-1276] [PMID]
22. Sudhindra R, Sahayo BJ. A study of serum uric acid in diabetes mellitus and prediabetes in a south Indian tertiary care hospital. Nitte University Journal of Health Science. 2012; 2(2):18-23.
23. Safi AJ, Mehmood R, Khan MA. Association of Serum Urinc eAcid with Type II Diabetes Mellitus. Journal of Postgraduate Medical Institute (Peshawar-Pakistan). 2011; 18(1): 59-63.
24. Krishnan E, Akhras K, Sharma H, et al. Relative and attributed diabetes risk associated with hyperuricemia in US veterans with gout. QJM: An International Journal of Medicine. 2013; 106(8): 721-729. [DOI:10.1093/qjmed/hct093] [PMID] [PMCID]
25. Mirzapour A, Hosseini SR, Hosseini SM, et al. The relationship between serum uric acid and blood sugar levels in the elderly diabetic patients of amirkola city. Journal of Babol University of Medical Sciences. 2015; 17(2): 1-6.
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