en بهداشت عمومی Public Health گزارش کوتاه Short Communication <p><strong>Abstract</strong></p> <p><strong>Introduction:</strong> Thalassemia is regarded as a genetic hematologic disease that affects various aspects of patients’ life. Measuring the health-related quality of life is a multidimensional concept that focuses on the disease as well as its treatment.</p> <p><strong>Materials and methods</strong>:  This  cross-sectional study consisted of  50 adolescents aged 12-18 years suffering from Thalassemia major, out of which 30 were females and 20 were males with the mean (±SD) age of 15.38(±2) years old. The present study was carried out  applying the  Kidscreen-27 health-related questionnaire.</p> <p><strong>Results</strong><strong>:</strong> There was no statistically significant difference between urban and rural patients’ scores (P-value=0.22). Comparison of quality of life amongst female and male patients indicated  male patients&#39 better scores in regard with physical well-being, psychosocial well-being and the total score of quality of life compared to the females (P-value<0.05). The total score of quality of life within adolescents with higher educated  fathers was reported to be slightly higher than that of the other groups.</p> <p><strong>Conclusion:</strong> The study findings revealed that there was neither a significant difference between urban and rural patients with thalassemia major, nor a relation between adolescent patients&#39  quality of life  and their fathers’ education level. Nonetheless, male patients were demonstrated to have better quality of lifethan females.</p> Adolescents, Kidscreen-27, Quality of life, Thalassemia major 234 238 http://jhr.ssu.ac.ir/browse.php?a_code=A-10-1117-3&slc_lang=en&sid=1 Sadati Sadati سروناز ساداتی No 1. Medical student, Babol University of medical Sciences, Babol, Iran. Tamaddoni Tamaddoni احمد تمدنی No 2. Pediatric Department, Babol University of Medical Sciences, Babol, Iran Mohammad hossein baghianimoghadam محمدحسین باقیانی مقدم baghianimoghdam@yahoo.com Yes