Journal of Community Health Research

en Survival Analysis of Ovarian Cancer Patients in Yazd City, Central part of Iran, 1999-2018 اپیدمیولوژی Epidemiology پژوهشي Research <div style="text-align: justify;">Background: Ovarian Cancer (OC) as a common gynecologic cancer according to mortality rate has the seventh rank among women in the world. This study aimed to identify risk factors associated with OC survival in Yazd, Iran. Methods: In this observational retrospective cohort study, the medical records of 150 patients who were definitively diagnosed with OC from 1999 to 2018 were investigated. The Kaplan–Meier estimator and the Cox proportional hazard model with hazard ratio and the log-rank test were used for data analysis. All statistical analyses were done in R 4.0.5, package survival. Results: 60.77% (91 people) of patients were under 60 years old. 32.7% (49 people) were in stage III of the disease. 62% (93 people) did not have ascites, 67.3% (101 people) had disease-free survival more than 65 months. 45 (30%) of 150 patients were dead. Median survival time was 96 months (95% CI∶57.20 to 134.79), one, three, five-, and ten-year survival rates were 83,73,55 and 33 months; respectively. Log-rank test results showed there was a significant difference between age, stage, ascites, disease-free survival, and Treatment method, CA125 after and before treatment (p < 0.05). Cox proportional hazard model result showed ascites (HRadj = 3.89, 95% CI: 1.35 to 11.15, P = 0.01) and DFS (HRadj = 23.52, 95 % CI: 4.21to128.33, p = < 0.001) as significant covariates. Conclusion: The results of our study showed that disease-free survival and ascites are the main risk factors for OC and paying attention to them will be effective in increasing patient survival.</div> Ovarian cancer, survival, cox proportional hazard, Iran 77 86 http://jhr.ssu.ac.ir/browse.php?a_code=A-10-1792-2&slc_lang=en&sid=1 Maryam Arabi maryamarabi273@gmail.com 0000-0002-3169-0564 No Center for Healthcare Data Modeling, Departments of biostatistics and Epidemiology, School of public health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Farzan Madadizadeh madadizadehfarzan@gmail.com 0000-0002-5757-182x Yes Center for Healthcare Data Modeling, Departments of biostatistics and Epidemiology, School of public health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mohammadreza Mortazavizadeh Mortazavizadeh@iauyazd.ac.ir 0000-0002-9734-3813 No Assistant Professor,Aliebn Abitaleb School Of Medicince, Islamic Azad University,Yazd,Iran Hossien Fallahzadeh hofaab@yahoo.com 0000-0001-6518-366X No Center for Healthcare Data Modeling, Departments of biostatistics and Epidemiology, School of public health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran