Methods: The present analytic cross sectional study was done on the cancer registry data of Yazd province for the evaluation of trend of genital carcinoma occurrence amongst females from 2006 to 2010. The trend of cancer incidence was calculated according to age, year of occurrence, family history, income, and job and residence place. Data was analyzed using student T-test and chi-square test.

 Findings: There were seen higher percentages of cancer amongst age above 50 years, married women and householders. Majority of those had education level of primary (%40.5) and moderate income level (%49.6). The highest incidence rate was related to year 2010 (%30) and uterus cancers including body & endometrial was more common than others ( %42.7). The association between cancer incidence and age (p<.001) also disease occurrence and marital status (p=.03) were seen statistically significant. Cancers of uterus and cervix among subjects with age above 50 and cancer of ovary among females under 30 years was more common.

 Conclusion: our results showed that the incidence rate of genital carcinoma amongst Yazdi females has had a increasing trend from 2006 to 2010 and socio- economic factors had significant role in the causation of cancer. This is the same indicators coming from developing countries where community health is influencing from socio-economic and environmental changes.