Introduction: The purpose of the present study was to examine the validity and reliability of the Health Related Quality of Life Questionnaire (KIDSCREEN-52) in a sample of Iranian students. Materials and Method: Using Multistage Sampling, 551 students from middle and high school, studying in Yazd city were selected as a sample. In this study” KIDSCREEN-52 HRQOL questionnaire”, and some other questionnaires that assess similar construct were employed. To examine the validity of the questionnaire, construct validity (confirmatory factor analysis and diagnosis validity) and convergent validity were used and Cronbach Alfa coefficient and test -retest reliability were also used to examine the reliability of the scale. Results: Confirmatory factor analysis indicated that the root mean square error of approximation (RMSEA) and comparative fit index (CFI) values were 0.053 and 0.97 respectively, showing an excellent (adequate) fitness between the specified model and the observed data. However, the obtained convergent validity indicated that the relationship among KIDSCREEN-52 dimensions with other similar constructs, except for social acceptance and bulling, were moderate to high and significant. Differences in KIDSCREEN-52 dimensions were also found based on mental health and socio-economic status. All Alfa coefficients (except for social acceptance and bulling) and test- retest reliability coefficient (two week distance) were acceptable. Conclusions: The KIDSCREEN-52 questionnaire has a good validity and reliability in Iranian student population.

Keywords: quality of life, health related quality of life, Kidscreen-52, validity, reliability, health policy

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